ZP3022, CAS 1345835-12-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: L-histidylglycyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-a-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginyl-2- [2-(2-aminoethoxy)ethoxy] acetyl-2-[2- (2-aminoethoxy)ethoxy] acetyl-L-tyrosylglycyl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-phenylalaninamide

Purity: ≥95%

Formula Markup: C199H294N48O61S

Formula Weight: 4366.9

CAS Number: 1345835-12-2

Notes: A dual GLP-1R and CCK2 receptor agonist; selectively increases cAMP accumulation or ERK phosphorylation in HEK293 cells expressing GLP-1R or the CCK2 receptor (EC50s = 0.02 and 10.3 nM, respectively, for the human receptors) over ERK phosphorylation in HEK293 cells expressing the CCK1 receptor (EC50 = >1,000 nM); increases the proliferation of neonatal rat β-cells in vitro at 40 nM; increases GSIS in rat pancreatic islets at 10 and 100 nM; reduces body weight in rats at 40 nmol/kg twice per day; increases β-cell mass and total pancreas mass and improves glucose tolerance in db/db mice at 100 nmol/kg per day

• SKU: CAY42636-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42636-10
• Package Unit: 10 mg
• Quantity Unit: STK