KEA1-97, CAS 2138882-71-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine

Purity: ≥98%

Formula Markup: C15H9Cl2FN4

Formula Weight: 335.162723

CAS Number: 2138882-71-8

Notes: An inhibitor of the protein-protein interaction between Trx and caspase-3; binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM); inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM; reduces survival and proliferation of and induces apoptosis in Trx-overexpressing 231MFP breast cancer cells; reduces tumor volume in a 231MFP mouse xenograft model at 5 mg/kg

• SKU: CAY42049-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42049-50
• Package Unit: 50 mg
• Quantity Unit: STK