Lipid 12T-O14

Shelf life (days): 730.0

Formulation: A solid

Formal Name: tetradecyl 3-((4-((4-decylphenyl)amino)-4-iminobutyl)thio)propanoate

Purity: ≥95%

Formula Markup: C37H66N2O2S

Formula Weight: 602.99822

Notes: An amidine-incorporated degradable lipid (pKa 8.15); has been used in the generation of LNPs for the delivery of siRNA and mRNA in vitro or in vivo; LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells; intramuscular delivery of LNPs containing lipid 12T-O14 and encapsulating SARS-CoV-2 spike-encoding mRNA increases anti-SARS-CoV-2 spike protein IgG titers in mice in a prime and boost immunization regimen; LNPs containing lipid 12T-O14 accumulate in the liver, but LNPs containing both lipid 12T-O14 and MC3 can be tuned to target the lungs or the spleen

• SKU: CAY41946-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41946-10
• Package Unit: 10 mg
• Quantity Unit: STK