DMT7

Shelf life (days): 365.0

Formulation: A solution in ethanol

Formal Name: 1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea

Purity: ≥90%

Formula Markup: C42H79N3S

Formula Weight: 658.2

Notes: An ionizable cationic lipid (pKa = 6.5); has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo; LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis; the same LNPs decrease the number of Tregs, increase the number of tumor-associated M1 macrophages, and increase intratumoral levels of Il-12, Il-2, Tnf-a, and Ifn-? in a B16/F10 murine melanoma model

• SKU: CAY41389-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41389-5
• Package Unit: 5 mg
• Quantity Unit: STK