THP1 Lipid

Shelf life (days): 1460.0

Formulation: A solution in ethanol

Formal Name: diethyl 1,3-dioctyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

Purity: ≥98%

Formula Markup: C26H48N2O4

Formula Weight: 452.6704

Notes: An ionizable cationic lipid (pKa = 5.451); has been used in the generation of LNPs for the deliver of mRNA in vitro and in vivo; LNPs containing THP1 lipid and encapsulating mRNA encoding luciferase induce luciferase expression in HEK293 and RAW 264.7 cells; LNPs containing THP1 lipid and 1,2-POPE accumulate in mouse liver after intravenous administration and have a higher transfection efficiency than LNPs containing DLin-MC3-DMA; THP1 lipid-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the liver of Ai14 mice engineered to express tdTomato upon Cre-mediated recombination

• SKU: CAY42585-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42585-5
• Package Unit: 5 mg
• Quantity Unit: STK