Shelf life (days): 1460.0
Formulation: A solid
Formal Name: androstane-3ß,5a,6ß-triol
Purity: ≥98%
Formula Markup: C19H32O3
Formula Weight: 308.5
CAS Number: 4725-51-3
Notes: Annaosanchun is a synthetic sterol and neuroprotectant agent.{69662} It increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM. Annaosanchun (10 µM) prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons.{69663} It reduces neurological and neuromuscular deficits and infarct volume in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at doses of 0.5, 2, or 10 mg/kg.
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