Shelf life (days): 1460.0
Formulation: A solution in ethanol
Formal Name: 1,1'-[[3-[4-[2-[[3-[bis(2-hydroxytetradecyl)amino]-2-ethoxypropyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis-2-tetradecanol
Purity: ≥95%
Formula Markup: C86H177N5O7
Formula Weight: 1393.35508
CAS Number: 2639634-82-3
Notes: An ionizable cationic lipid (pKa = 5.94); has been used in the generation of LNPs for the delivery of mRNA in vivo; C14-490-containing LNPs accumulate primarily in the fetal mouse liver and, to a lesser extent, in the lungs, intestine, and brain after vitelline vein injection on E16; CD45-functionalized LNPs containing C14-490 and encapsulating mRNA encoding GFP transfect Jurkat cells; C14-490-containing CD45-functionalized LNPs encapsulating Cre mRNA mediate genome modulation in bone marrow HSCs for at least four months after in utero injection in R26mT/mG mice at E13.5
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