Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 21-(acetyloxy)-6a,9-difluoro-11ß-hydroxy-16a,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Purity: ≥98%
Formula Markup: C26H32F2O7
Formula Weight: 494.5
CAS Number: 356-12-7
Notes: Fluocinonide is a synthetic fluorinated corticosteroid that binds to the glucocorticoid receptor and has anti-inflammatory properties.{41241,41242} It prevents inflammation and epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014). Fluocinonide inhibits tumor promotion and DNA synthesis in mouse epidermis when applied topically at a dose of 10 µg/0.2 ml. It also acts as an agonist at the smoothened (Smo) receptor with an EC50 value of 1,000 nM in a ligand displacement assay in cells overexpressing the Smo receptor.{41243} Formulations containing fluocinonide are used in the treatment of various skin conditions, including psoriasis and atopic dermatitis.
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