Shelf life (days): 365.0
Formulation: A solution in ethanol:water (95:5)
Formal Name: 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-d5-eicosatetraenoic acid, methyl ester
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C31H44D5N3O9S
Formula Weight: 644.8
Notes: Leukotriene C4-d5 (LTC4-d5) methyl ester is intended for use as an internal standard for the quantification of LTC4 methyl ester by GC- or LC-MS. LTC4 is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396} LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.
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