Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (E)-3-((2-methoxyethyl)(methyl)amino)acrylate
Purity: ≥95%
Formula Markup: C34H57NO3
Formula Weight: 527.834
Notes: A sterol lipid; has been used in the generation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing N-sterol and encapsulating mRNA encoding a reporter are uptaken via clathrin-coated pits, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis with different frequencies in a lipid composition-dependent manner in J774A.1 macrophages; The same LNPs demonstrate improved endosomal escape in J774A.1 macrophages over LNPs containing SM-102; N-sterol LNPs encapsulating an mRNA reporter selectively accumulate in mouse spleens
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