Product Description: 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Applications: COVID-19-immunoregulation
Formula: C21H30O3
References: [1]Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13./[2]Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.
CAS Number: 600-57-7
Molecular Weight: 330.468
Compound Purity: 99.91
Research Area: Cardiovascular Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: 11β-HSD
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