7α,25-Dihydroxycholesterol, CAS 64907-22-8

7α,25-Dihydroxycholesterol, CAS 64907-22-8
SKU
MEXHY-113962-10.1
Packaging Unit
10 mM/1 ml
Manufacturer
MedChemExpress

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Product Description: 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C27H46O3

References: [1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23./[2]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.

CAS Number: 64907-22-8

Molecular Weight: 418.65

Compound Purity: 99.88

Research Area: Inflammation/Immunology

Solubility: DMSO : 4.55 mg/mL (ultrasonic)/Ethanol : < 1 mg/mL

Target: EBI2/GPR183;Endogenous Metabolite
More Information
SKU MEXHY-113962-10.1
Manufacturer MedChemExpress
Manufacturer SKU HY-113962-10.1
Package Unit 10 mM/1 ml
Quantity Unit STK
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