Product Description: 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C27H46O3
References: [1]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23./[2]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.
CAS Number: 64907-22-8
Molecular Weight: 418.65
Compound Purity: 99.88
Research Area: Inflammation/Immunology
Solubility: DMSO : 4.55 mg/mL (ultrasonic)/Ethanol : < 1 mg/mL
Target: EBI2/GPR183;Endogenous Metabolite
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