Groenlandicine, CAS 38691-95-1

Product Description: Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C19H16NO4+

References: [1]Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12./[2]Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.

CAS Number: 38691-95-1

Molecular Weight: 322.34

Compound Purity: 99.87

Research Area: Cancer; Metabolic Disease

Solubility: DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Topoisomerase

• SKU: MEXHY-N6865-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N6865-10
• Package Unit: 10 mg
• Quantity Unit: STK