Formulation: A solid
Formal Name: 1S,4aS,5R,6,7S,7aS-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C24H30O11
Formula Weight: 494,5
Shelf life (days): 1460
CAS Number: 19210-12-9
Notes: Harpagoside is an iridoid glycoside that has been found in H. procumbens, also known as devil’s claw, and has diverse biological activities.{66596,66597,66598} It inhibits LPS-induced increases in COX-2 and nitric oxide (NO) levels, as well as TNF mRNA expression in HepG2 cells when used at concentrations ranging from 50 to 200 µM.{66596} In vivo, harpagoside (10 mg/kg) reduces synovial inflammation, joint destruction, and bone erosion in a mouse model of collagen-induced arthritis.{66597} It also decreases substantia nigra pars compacta neuronal cell death and increases time spent on the rod in a rotarod test in a mouse model of MPTP-induced Parkinson’s disease.{66598}
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