Formulation: A crystalline solid
Formal Name: (2E)-3-(3,4-dihydroxyphenyl)-1-[4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one
Purity: ≥95%
Formula Markup: C21H22O11
Formula Weight: 450,4
Shelf life (days): 1460
CAS Number: 535-96-6
Notes: Marein is a glucoside chalcone that has been found in C. tinctoria and has diverse biological activities, including antioxidant, enzyme inhibitory, antidiabetic, and anti-inflammatory properties.{58297,58298,58299} It scavenges DPPH (Item No. 14805) radicals (IC50 = 48.35 μM) in a cell-free assay and is an inhibitor of EGFR (IC50 = 19.94 μM).{58297,58298} Marein (50 mg/kg) reduces fasting blood glucose and fasting serum levels of insulin, triglycerides, LDL cholesterol, and total cholesterol in diabetic db/db mice.{58299} It also reduces serum and renal IL-6 and chemokine (C-C motif) ligand 2 (CCL2) levels, as well as decreases kidney fibrosis, in db/db mice.
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