Product Description: Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].
Applications: Neuroscience-Neurodegeneration
Formula: C14H18N2O5
References: [1]Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62. /[2]Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96. /[3]Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9./[4]Lehman-McKeeman LD, et al. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett. 1999 Dec 20;111(1-2):105-15./[5]An J, et al. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. Mol Med Rep. 2021 Jun;23(6):450.
CAS Number: 81-14-1
Molecular Weight: 294.307
Compound Purity: 99.41
Research Area: Neurological Disease
Solubility: DMSO : ≥ 125 mg/mL
Target: Akt;Apoptosis;Cytochrome P450;PI3K
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