Product Description: Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively[1][2][3].
Formula: C29H38O10
References: [1]1.Fu Y, et al. Myrothecine A modulates the proliferation of HCC cells and the maturation of dendritic cells through downregulating miR-221. Int Immunopharmacol. 2019 Oct;75:105783. /[2]2.Lin T, et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J Agric Food Chem. 2014 Jun 25;62(25):5993-6000. /[3]3.Song H, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24(12):2291.
CAS Number: 910292-40-9
Molecular Weight: 546.61
Research Area: Cancer
Target: Apoptosis;Bcl-2 Family;Caspase;Cytochrome P450;JNK;PARP
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