Product Description: Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
Applications: COVID-19-immunoregulation
Formula: C30H46O8
References: [1]Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237./[2]Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.
CAS Number: 466-07-9
Molecular Weight: 534.68
Compound Purity: 99.43
Research Area: Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Apoptosis;Atg8/LC3;Beclin1;Na+/K+ ATPase
English
Deutsch
