Product Description: 1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) promotes the gene expressions of CYP1A1, CYP1B1, and aryl hydrocarbon receptor repressor (AhRR) in human peripheral blood lymphocytes (PBLs). 1,2,3,4,7,8-Hexachlorodibenzofuran activates the ethoxyresorufin-Odeethylase, achieves 20% of the maximum response caused by TCDD with a BMR20TCDD of 0.115-0.143 nM[1].
Formula: C12H2Cl6O
References: [1]van Ede KI, et al., Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol Lett. 2014 Apr 7;226(1):43-52.
CAS Number: 70648-26-9
Molecular Weight: 374.86
Research Area: Others
Target: Aryl Hydrocarbon Receptor;Cytochrome P450