Product Description: 2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively)[1][2].
Formula: C12H2Cl6O
References: [1]Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29(3):677-84. /[2]Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131-44.
CAS Number: 60851-34-5
Molecular Weight: 374.86
Research Area: Cancer; Infection
Target: Others
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