3-Cl-Pyridine-amide-acrylaldehyde-piperazine

Product Description: 3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate of LO-4-25 (HY-176067). LO-4-25 is an androgen receptor (AR) DNA binding domain ligand linked via a linker to the truncated fumaramide handle. LO-4-25 shows robust degradation of both AR and AR-V7 in 22Rv1 cells[1].

Applications: Cancer-programmed cell death

Formula: C13H15ClN4O2

References: [1]Lauren M Orr, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. bioRxiv. April 25, 2025.

Molecular Weight: 294.74

Research Area: Cancer

Target: Androgen Receptor

• SKU: MEXHY-176068-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-176068-25
• Package Unit: 25 mg
• Quantity Unit: STK