Product Description: 5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC50 of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects[1].
Formula: C22H18N6O4
References: [1]Aziz MA, et al. Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. Bioorg Chem. 2025 Mar;156:108181.
Molecular Weight: 430.42
Research Area: Inflammation/Immunology
Target: Lipoxygenase;NO Synthase