Product Description: 5A2-SC8 TFA is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 TFA LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models[1][2][3].
Applications: Cancer-programmed cell death
Formula: C93H173N5O20S5.xC2HF3O2
References: [1]Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525./[2]Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022): 3973-3986./[3]Johnson, et al. The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes. Diss. 2022.
Molecular Weight: 1841.72 (free base)
Compound Purity: 98.56
Research Area: Cancer
Target: Liposome
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