AA-BR-157

Product Description: AA-BR-157 is a PROTAC degrader for metallothionein 2A (MT2A) with a DC50 of 190 nM. AA-BR-157 downregulates the cytoskeleton and cell motility regulating protein DIAPH3, inhibits the migration of MDA-MB-231 and U-87 MG. AA-BR-157 regulates the zinc homeostasis in MDA-MB-231[1]. (Pink: ligand for target protein MT2A ligand 1 (HY-168970); Black: linker (HY-119429); Blue: ligand for VHL E3 ligase (HY-125845))

Formula: C56H70N8O11S2

References: [1]Racioppo B, et al., Chemoproteomics-Enabled De Novo Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer. J Am Chem Soc. 2025 Mar 5;147(9):7817-7828.

Molecular Weight: 1095.33

Research Area: Cancer

Target: PROTACs

• SKU: MEXHY-168969-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168969-0
• Package Unit: Get quote
• Quantity Unit: STK