Product Description: Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.
Applications: Neuroscience-Neurodegeneration
Formula: C5H10NO4S.1/2Ca
References: [1]Preuss UW.
Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).
Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x./[2]Witkiewitz K, Saville K, Hamreus K.
Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.
Ther Clin Risk Manag. 2012;8:45-53./[3]Gahr M, et al.
Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15./[4]Palucha-Poniewiera A, Pilc A.
Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6./[5]Hinton DJ, et al.
Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.
Neuropharmacology. 2012 Jun;62(8):2480-8./[6]Pradhan G, et al., Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice. Psychopharmacology (Berl). 2018 Jul;235(7):2027-2040./[7]Allgaier C, et al., Acamprosate inhibits Ca2+ influx mediated by NMDA receptors and voltage-sensitive Ca2+ channels in cultured rat mesencephalic neurones. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):440-3.
CAS Number: 77337-73-6
Molecular Weight: 200.24
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: DMSO : < 1 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: GABA Receptor;iGluR
English
Deutsch
