ADH-6 (TFA), CAS 2990065-87-5

Product Description: ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases[1].

Applications: Cancer-programmed cell death

Formula: C31H37F3N8O11

References: [1]Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.

CAS Number: 2990065-87-5

Molecular Weight: 754.67

Compound Purity: 99.91

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;MDM-2/p53

• SKU: MEXHY-145785A-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145785A-100
• Package Unit: 100 mg
• Quantity Unit: STK