AF615, CAS 122510-61-6

Product Description: AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].

Formula: C10H13N5O2S

References: [1]Nikolaos Karantzelis, et al. Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Front Pharmacol. 2022 Apr 25;13:860682.

CAS Number: 122510-61-6

Molecular Weight: 267.31

Research Area: Cancer

Target: DNA/RNA Synthesis

• SKU: MEXHY-171180-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171180-0
• Package Unit: Get quote
• Quantity Unit: STK