AG-012986, CAS 486414-35-1

Product Description: AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis[1].

Formula: C22H23F2N5O2S

References: [1]Zhang C, et al. Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy. Mol Cancer Ther. 2008 Apr;7(4):818-28.

CAS Number: 486414-35-1

Molecular Weight: 459.51

Research Area: Cancer

Target: Apoptosis;CDK

• SKU: MEXHY-119715-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-119715-0
• Package Unit: Get quote
• Quantity Unit: STK