Agomelatine (Standard), CAS 138112-76-2

Agomelatine (Standard), CAS 138112-76-2
SKU
MEXHY-17038R-1
Packaging Unit
1 mg
Manufacturer
MedChemExpress

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Product Description: Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

Formula: C15H17NO2

References: [2]Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64./[3]Aguiar CC, et al. Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol. 2013 Aug;33(6):825-35./[1]Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61.

CAS Number: 138112-76-2

Molecular Weight: 243.30

Research Area: Neurological Disease

Target: 5-HT Receptor;Endogenous Metabolite;Melatonin Receptor;Reference Standards
More Information
SKU MEXHY-17038R-1
Manufacturer MedChemExpress
Manufacturer SKU HY-17038R-1
Package Unit 1 mg
Quantity Unit STK
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