Product Description: AKU-005 is a FAAH and MAGL dual inhibitor with IC50 values of 63, 389 nM for rat and human FAAH, respectively. AKU-005 has the potential for the research of trigeminal hyperalgesia[1][2].
Formula: C20H21N5O
References: [1]Greco R, et al. Effects of the Dual FAAH/MAGL Inhibitor AKU-005 on Trigeminal Hyperalgesia in Male Rats. Cells. 2024 May 13;13(10):830. /[2]Aaltonen N, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90.
CAS Number: 1515855-85-2
Molecular Weight: 347.41
Compound Purity: 99.48
Research Area: Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target: FAAH;MAGL