AKV-9, CAS 1307262-15-2

Product Description: AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC50 of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan[1].

Formula: C16H14F6O3

References: [1]Zhang Y, et al., Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS Med Chem Lett. 2012 May 22;3(7):584-587.

CAS Number: 1307262-15-2

Molecular Weight: 368.27

Compound Purity: 99.98

Research Area: Neurological Disease

Solubility: DMSO : 116.67 mg/mL (ultrasonic)

Target: SOD

• SKU: MEXHY-169904-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169904-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK