AMG-3969, CAS 1361224-53-4

Product Description: AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.

Applications: Metabolism-sugar/lipid metabolism

Formula: C21H20F6N4O3S

References: [1]Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40./[2]Nishimura N, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J Med Chem. 2014 Apr 10;57(7):3094-116./[3]St Jean DJ Jr, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J Med Chem. 2014 Jan 23;57(2):325-38.

CAS Number: 1361224-53-4

Molecular Weight: 522.46

Compound Purity: 99.62

Research Area: Metabolic Disease

Solubility: DMSO : ≥ 100 mg/mL

Target: Glucokinase

• SKU: MEXHY-12411-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12411-25
• Package Unit: 25 mg
• Quantity Unit: STK