AMG-628, CAS 862269-93-0

Product Description: AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats[1].

Formula: C25H25FN6O2S

References: [1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50(15):3528-39.

CAS Number: 862269-93-0

Molecular Weight: 492.57

Research Area: Neurological Disease

Target: TRP Channel

• SKU: MEXHY-W931056-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W931056-0
• Package Unit: Get quote
• Quantity Unit: STK