Antidepressant agent 8, CAS 3066104-04-6

Product Description: Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583)-induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier[1].

Applications: Neuroscience-Neurodegeneration

Formula: C18H23FN4OS2

References: [1]Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65(2):857-872.

CAS Number: 3066104-04-6

Molecular Weight: 394.53

Research Area: Neurological Disease

Target: iGluR

• SKU: MEXHY-170898-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170898-0
• Package Unit: Get quote
• Quantity Unit: STK