Product Description: Antiparasitic agent-26 (Compound 8) is an antiparasitic compound that potently inhibits the growth of Naegleria fowleri, with IC50 values of 22.87 μM (trophozoite stage) and 25.16 μM (cyst stage). Antiparasitic agent-26 exerts its antiparasitic activity by inducing programmed cell death, including cytoplasmic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be used in the research of primary amoebic meningoencephalitis (PAM)[1].
Formula: C17H17NO5
References: [1]Ben Youssef M, et al. Amoebicidal thymol analogues against brain-eating amoeba, Naegleria fowleri. Bioorg Chem. 2025 Mar 6;159:108346.
Molecular Weight: 315.32
Research Area: Infection; Inflammation/Immunology
Target: Parasite;Reactive Oxygen Species
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