Antitumor agent-195

Product Description: Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model[1].

Formula: C22H22N2O4

Molecular Weight: 378.42

Research Area: Cancer

Target: Quinone Reductase;STAT

• SKU: MEXHY-170947-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170947-0
• Package Unit: Get quote
• Quantity Unit: STK