Product Description: Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer activity, showing an IC50 of 90 nM against MCF-7 breast cancer cells.Antitumor agent-196 promotes Apoptosis by regulating the Bax-caspase 3 signaling pathway, and induces Ferroptosis through the modulation of key signaling molecules, including GPX4.Antitumor agent-196 holds promising potential for further research in the field of cancer therapy[1].
Formula: C51H81NO15
References: [1]Jiang B, et al. Anti-tumor effects of artemisinin-based oligomers: From monomer to trimer as a novel drug-enhancing strategy. Eur J Med Chem. 2025 Apr 5;287:117313.
CAS Number: 2705841-17-2
Molecular Weight: 948.19
Research Area: Cancer
Target: Apoptosis;Caspase;Ferroptosis