Arimoclomol, CAS 289893-25-0

Product Description: Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol can be used for the study of Niemann–Pick disease type C.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C14H20ClN3O3

References: [1]Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92./[2]Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

CAS Number: 289893-25-0

Molecular Weight: 313.78

Research Area: Metabolic Disease; Inflammation/Immunology; Neurological Disease

Solubility: 10 mM in DMSO

Target: HSP

• SKU: MEXHY-106443-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-106443-10
• Package Unit: 10 mg
• Quantity Unit: STK