ATX inhibitor 25, CAS 2951100-44-8

Product Description: ATX inhibitor 25 (Compound 29) is an orally active Autotaxin inhibitor with an IC50 of 1.08 nM. ATX inhibitor 25 exhibits excellent in vitro metabolic stability, with a t1/2 of more than 170 minutes. In the bleomycin (HY-108345)-induced pulmonary fibrosis mouse model, orally administered ATX inhibitor 25 shows anti-fibrotic effects[1].

Applications: COVID-19-immunoregulation

Formula: C23H20ClFN4O5

References: [1]Ma D, et al. Development of potent indole-3-carboxamide autotaxin inhibitors with preferred lipophilicity for in vivo treatment of pulmonary fibrosis. Eur J Med Chem. 2025 Apr 15;288:117398.

CAS Number: 2951100-44-8

Molecular Weight: 486.88

Research Area: Inflammation/Immunology

Target: Phosphodiesterase (PDE)

• SKU: MEXHY-168930-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168930-0
• Package Unit: Get quote
• Quantity Unit: STK