ATX inhibitor 26, CAS 2940248-11-1

Product Description: ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. ATX inhibitor 26 inhibits cell migration and collagen gel contraction. ATX inhibitor 26 has significant anti-fibrotic effects, reducing collagen deposition in a Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis model[1].

Applications: COVID-19-immunoregulation

Formula: C18H19Cl2N7O3

References: [1]Kim M, et al. Targeting Autotaxin with imidazole- and Triazolyl-based inhibitors: Biological insights from in vitro and in vivo studies in pulmonary fibrosis. Bioorg Chem. 2025 Jun 15; 160:108426.

CAS Number: 2940248-11-1

Molecular Weight: 452.29

Research Area: Inflammation/Immunology

Target: ERK;JNK;p38 MAPK;Phosphodiesterase (PDE)

• SKU: MEXHY-173483-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173483-0
• Package Unit: Get quote
• Quantity Unit: STK