Aurora-A ligand 1, CAS 2541626-73-5

Product Description: Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1].

Formula: C21H23N5O3

References: [1]Tang J, et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6.

CAS Number: 2541626-73-5

Molecular Weight: 393.44

Research Area: Cancer

Target: Aurora Kinase;Ligands for Target Protein for PROTAC

• SKU: MEXHY-168440-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168440-0
• Package Unit: Get quote
• Quantity Unit: STK