Product Description: Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].
Applications: COVID-19-immunoregulation
Formula: C21H35Cl2MnN5
References: [1]Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.
CAS Number: 435327-40-5
Molecular Weight: 483.38
Compound Purity: 96.02
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : ≥ 230 mg/mL
Target: Reactive Oxygen Species
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