Product Description: BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research[1].
Formula: C24H32N2O4
References: [1]McGarry DJ, et al. A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids. ACS Chem Biol. 2016 Dec 16;11(12):3300-3304.
CAS Number: 2059099-03-3
Molecular Weight: 412.52
Research Area: Others
Target: Biochemical Assay Reagents;Drug Intermediate
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