Formulation: A solid
Formal Name: N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-1-propanamine, monohydrochloride
Purity: ≥95%
Formula Markup: C19H23N3O • HCl
Formula Weight: 345,9
Shelf life (days): 1460
CAS Number: 132-69-4
Notes: Benzydamine is a non-steroidal anti-inflammatory drug (NSAID).{69600} It decreases the viability of THP-1 monocytes, Saos-2 osteosarcoma, and HGF-1 gingival cancer cells (IC50s = 59.08, 30.79, and 52.06 µg/ml, respectively). Benzydamine (10 µg/ml) reduces LPS-induced increases in the levels of IL-6 and TNF-α secreted by THP-1 cells. It decreases the levels of prostaglandin E2 (PGE2; Item No. 14010) and PGF1α (Item No. 15010) in unstimulated or IL-1β- or TNF-α-stimulated primary human gingival fibroblasts when used at a concentration of 1 µM.{69601} Benzydamine (100 mg/kg) reduces hydrochloric acid levels and increases mucin levels in gastric juices isolated from rats.{69602} It inhibits carrageenan-induced paw edema in rats when administered orally at a dose of 60 mg/kg or applied topically at 3% (w/w).{69603} Formulations containing benzydamine have been used in the treatment of acute sore throat. This product is also available as an analytical reference standard (Item No. 15161).
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