BET-IN-28

Product Description: BET-IN-28 (Compound 44) is a highly potent inhibitor of bromodomain and extra-terminal domain (BET), with an IC50 value of 4.47 nM against BRD4-BD1. BET-IN-28 blocks the interaction between BET proteins and N-acetylated lysine residues on histone tails, down-regulates certain genes. BET-IN-28 can be used for hematological malignancies and solid tumors study[1].

Formula: C26H29N9O2

References: [1]Zaidi JM, et al. Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold. ACS Med Chem Lett. 2025 Mar 21;16(4):588-595.

Molecular Weight: 499.57

Research Area: Cancer

Target: Epigenetic Reader Domain

• SKU: MEXHY-170226-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170226-0
• Package Unit: Get quote
• Quantity Unit: STK