BKCa activator-1

Product Description: BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model[1].

Formula: C22H23F7N2O3

References: [1]Park SB, et al., Discovery of Diphenyl Ether Derivatives as Novel BKCa Channel Activators: Structure-Activity Relationship, Cryo-EM Complex Structures, and In Vivo Animal Studies. J Med Chem. 2025 Feb 27;68(4):4259-4286.

Molecular Weight: 496.42

Research Area: Others

Target: Potassium Channel

• SKU: MEXHY-170918-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170918-0
• Package Unit: Get quote
• Quantity Unit: STK