BMVC4, CAS 868843-84-9

Product Description: BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.

Applications: Cancer-programmed cell death

Formula: C26H23I2N5

References: [1]A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres

CAS Number: 868843-84-9

Molecular Weight: 659.30

Research Area: cancer

Target: Biochemical Assay Reagents

• SKU: MEXHY-111297-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111297-50
• Package Unit: 50 mg
• Quantity Unit: STK