BRD4 degrader-5

Product Description: BRD4 degrader-5 (Compound 23) is a hydrophobic tag (HyTag)-based protein degrader for BRD4 (DC50 = 24.7 μM) through ER stress and autophagy-lysosome pathway. BRD4 degrader-5 inhibits the proliferation of cancer cell 4T1 with an IC50 of 20.6 μM[1].

Formula: C35H42ClN7O2S

References: [1]Balestrero FC, et al., Versatile One-Pot Synthesis of Hydrophobic Tags by Multicomponent Reactions. ACS Omega. 2025 Jan 30;10(5):4745-4753.

Molecular Weight: 660.27

Research Area: Cancer

Target: AUTACs;Autophagy;Epigenetic Reader Domain

• SKU: MEXHY-170989-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170989-0
• Package Unit: Get quote
• Quantity Unit: STK