c-Fos-IN-1

Product Description: c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1].

Applications: Cancer-Kinase/protease

Formula: C28H35NO3

References: [1]Zhang H, et al. The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway. Eur J Med Chem. 2025 Mar 15;286:117291.

Molecular Weight: 433.58

Research Area: Cancer

Target: AP-1;Apoptosis;ERK

• SKU: MEXHY-168895-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168895-0
• Package Unit: Get quote
• Quantity Unit: STK