C-MS023

Product Description: C-MS023 is a photo-activatable MS023 (HY-19615) prodrug, achieving spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. C-MS023 inhibits PRMT6 mediated asymmetric dimethylation of H3 arginine 2 (H3R2me2a), with an estimate IC50 of 0.2224 μM. The photolysis of C-MS023 could be triggered by visible light irradiation at 420 nm, thereby liberating MS023 for effective downregulation of histone arginine asymmetric dimethylation and DNA replication-related transcriptomic activities[1].

Formula: C32H40N4O5

References: [1]Xu S, et al. Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition. J Med Chem. 2025 Feb 27;68(4):4373-4381.

Molecular Weight: 560.68

Research Area: Cancer

Target: Histone Methyltransferase

• SKU: MEXHY-168497-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168497-0
• Package Unit: Get quote
• Quantity Unit: STK